CONCLUSION
Clindamycin can inhibit DNAse I activity so that it can maintain the quality of human
genome DNA from saliva. Streptomycin cannot inhibit DNAse I activity so it cannot maintain
the DNA quality of the human genome of salivary origin. Clindamycin 3.2 mM effectively
inhibits DNAse I activity in human genome DNA of salivary origin while streptomycin does
not inhibit The quality of human genes of salivary origin and can be protected with clindamycin
0.1 mM with PCR can amplify human NOTCH2 genes while streptomycin cannot protect.
REFERENCES
Aas, J. A., Paster, B. J., Stokes, L. N., Olsen, I., & Dewhirst, F. E. (2005). Defining The Normal
Bacterial Flora Of The Oral Cavity. Journal Of Clinical Microbiology, 43(11), 5721–
5732. Google Scholar
Andreoni, F., Zürcher, C., Tarnutzer, A., Schilcher, K., Neff, A., Keller, N., Marques Maggio,
E., Poyart, C., Schuepbach, R. A., & Zinkernagel, A. S. (2017). Clindamycin Affects
Group A Streptococcus Virulence Factors And Improves Clinical Outcome. The Journal
Of Infectious Diseases, 215(2), 269–277. Google Scholar
Bertram, K. G. (1998). Basic And Clinical Pharmacology. Editions Appelton And Lange.
Stanford, Conn, 14, 16. Google Scholar
Bibi, T., Khurshid, Z., Rehman, A., Imran, E., Srivastava, K. C., & Shrivastava, D. (2021).
Gingival Crevicular Fluid (Gcf): A Diagnostic Tool For The Detection Of Periodontal
Health And Diseases. Molecules, 26(5), 1–16. Google Scholar
Fransiska, F. (2019). Ototoksisitas Aminoglikosida. Keluwih: Jurnal Kesehatan Dan
Kedokteran, 1(1), 36–46. Google Scholar
Garbieri, T. F., Brozoki, D. T., Dionisio, Thiago Jose, Santos, C. F., & Neves, L. T. Das. (2017).
Human Dna Extraction From Whole Saliva That Was Fresh Or Stored For 3,6 Or 12
Month Using Five Different Protocols. 25(2), 147–148. Google Scholar
Huque, A. K. M. M., So, W. M., You, M. K., & Shin, J. S. (2020). Phylogenetic Analysis And
In Vitro Bifunctional Nuclease Assay Of Arabidopsis Bbd1 And Bbd2. Molecules, 25(9),
2169. Google Scholar
Khare, P., Raj, V., Chandra, S., & Agarwal, S. (2014). Quantitative And Qualitative
Assessment Of Dna Extracted From Saliva For Its Use In Forensic Identification. Journal
Of Forensic Dental Sciences, 6(2), 81. Google Scholar
Kolarevic, A., Yancheva, D., Kocic, G., & Smelcerovic, A. (2014). Deoxyribonuclease
Inhibitors. European Journal Of Medicinal Chemistry, 88, 101–111. Google Scholar
Putri, N. P. P. E., & Yudianto, A. (2016). Pengaruh Tanah Dan Air Laut Terhadap Kualitas
Dna Dari Otot Psoas Jenazah Melalui Metode Str. Jurnal Biosains Pascasarjana Vol. 18,
18(3), 205. Google Scholar
Rodwell, V. W., Bender, D. A., Botham, K. M., Kennelly, P. J., & Weil, A. P. (2015).
Illustrated Biochemistry. New York: Mcgraw-Hill. Google Scholar
Rohmah, J., Cholifah, S., & Rezania, V. (2019). Pelatihan Higiene Dan Sanitasi Makanan Pada
Pedagang Makanan Di Kantin Sd. Loyalitas, Jurnal Pengabdian Kepada Masyarakat,
2(2), 170. Https://Doi.Org/10.30739/Loyal.V2i2.473 .Google Scholar
Spížek, J., & Řezanka, T. (2017). Lincosamides: Chemical Structure, Biosynthesis, Mechanism
Of Action, Resistance, And Applications. Biochemical Pharmacology, 133, 20–28.
Google Scholar
Syaifiatul, H. (2017). Dna Sebagai Bukti Untuk Memecahkan Tindakan Kriminal. Semin Nas
Humanira Apl Teknelogi Inf, 2017. Google Scholar
Takeshita, T., Kageyama, S., Furuta, M., Tsuboi, H., Takeuchi, K., Shibata, Y., Shimazaki, Y.,
Akifusa, S., Ninomiya, T., Kiyohara, Y., & Yamashita, Y. (2016). Bacterial Diversity In
Saliva And Oral Health-Related Conditions: The Hisayama Study. Scientific Reports, 6,